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A powerful disease that used to kill hundreds of peoples throughout North America, it spread so quickly that it brought an end to the War of Secession and each of its epidemy had an effect on the overall North American geo-political landscape (some used to call it the most powerful political force in North America). It's characterized by a heavy fever that kills a good number of those infected by it. It is spread by air.
William Wallace Lincoln
One of the epidemy "famous victim" was Abraham Lincoln's Son; some say that the death of his son led to a faster resolution of the conflict.