1559, Rome was reconquered by the Christians; all the Muslims found there were massacred.
In 1562, the great Sea battle of Malta was fought; the Seljuk-Barbary fleet was decimated.
1565, the Peace of Ostia was made. The Seljuks had to give up Latium (to Florence) and the Marches, Algiers, Tunis and Sicily (to the Triple Monarchy). The Romans displaced ~20 years ago returned in triumph. The victorious Italians demanded that the Pope returns to Rome, which the French king denied however.