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- February 1: The Democratic and Republican presidential primaries kick off with the Iowa caucus. For the Democrats, Former Secretary of State Hillary Clinton scores a razor thin victory over Vermont Senator Bernie Sanders, while Senator Ted Cruz of Texas scores a narrow victory over businessman Donald Trump of New York and Senator Marco Rubio of Florida. Subsequently, former Governor Mike Huckabee of Arkansas withdraws from the race.
- February 2: New Jersey Governor Chris Christie drops out of the race after losing the Iowa Caucus to Senator Cruz.
- February 17: Tapes from an unknown source reveal Donald Trump making lewd comments about women in 2005. The Rubio campaign uses this to their advantage and Trump's popularity crashes.
- February 20–23: Senator Marco Rubio wins the primaries in South Carolina and Nevada over businessman Donald Trump and Senator Ted Cruz.
- March 1: Senator Rubio wins the primaries in Georgia, Massachusetts, Minnesota, Vermont, and Virginia while Senator Cruz wins the primaries in Alabama, Alaska, Arkansas, Oklahoma, Tennessee, and his home state of Texas.
- March 2: Businessman Donald Trump drops out of the race after not winning any states on Super Tuesday. Senator Ted Cruz takes the lead in the primaries with Marco Rubio in second.
- March 5–12: Senator Cruz wins Super Tuesday after winning Kansas, Kentucky, Louisiana, Maine, Idaho, and Mississippi, while Senator Rubio wins Puerto Rico, Hawaii, and Washington D.C. and Governor Kasich wins Michigan.
- March 15: Senator Ted Cruz wins the primaries in Missouri and North Carolina, Senator Rubio wins his home state of Florida, and Governor Kasich wins Illinois and Ohio.
- June 7: Senator Marco Rubio wins the California primary, ultimately scoring more delegates than rival Senator Ted Cruz.
- June 8: Cruz suspends actively campaigning for the presidency, allowing Senator Rubio to become the presumptive nominee of the Republican Party.
- June 13: Former Presidents George W. Bush and George H. W. Bush officially endorse Marco Rubio for the presidency on live television.
- July 15: Senator Rubio announces Governor John Kasich of Ohio as his running mate for the 2016 election.
- July 18: The 2016 Republican National Convention commences.
- July 19: The second day of the convention oversees the second ballot. While it gives Senator Rubio a lead, he is still short of the 1,237 needed to secure the nomination.
- July 20: The third ballot is held at the Republican Convention between Senator Rubio and Senator Cruz. Rubio manages to secure all of Governor Kasich's delegates as well as those from New Mexico and Oklahoma; allowing him to pass the 1,237 delegate majority. Marco Rubio is officially nominated with his running mate John Kasich for President and Vice President.
- July 22: Secretary Clinton announces Senator Tim Kaine of Virginia will be her running mate for the election.
- September 26: The first presidential debate is held between Senator Marco Rubio (R-FL) and Secretary Hillary Clinton (D-NY). Clinton attacked Rubio for his lack of experience in Washington, however Rubio countered it citing that her experience highlights irresponsibility and poor conduct. Rubio maintains his lead in national polls with 47% to 41%.
- October 15: Rubio leads Hillary Clinton 48% to 41% after the last two debates. He holds a tight lead in the swing states of Ohio, Virginia, Pennsylvania, Colorado, and New Hampshire as well being tied with Clinton in New Jersey and Wisconsin.
- October 19: The third and final debate concludes between Secretary Clinton and Senator Rubio. Rubio continues to lead Clinton by 49% to 40%, nearly a 9-point margin.
- Main Article: United States presidential election, 2016