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The Roman Catholic Church is the largest Christian denomination in the world. During the Caroline Era, it has undergone a number of revolutionary changes, partly as a result of the invalid nature of Pope Peter II, who suffered a heart attack and possibly considerable brain damage early in his reign. This enabled the moderate tendency in the Church to dominate and change doctrine in several ways: they allowed the use of contraception, allowed priests to marry, began to admit women priests and drew much closer to the Protestant denominations.