1450/51: After a short war with Egypt, where they demonstrate their military power (cannons, large standing army), the Rum-Seljuks make the former one a tributary. Now Persia is the only other major Muslim power left.
1453: Aragonese troops land in Calabria, winning some battles in the beginning. When the main army of the Seljuks arrives, they're beaten back to Sicily, however. In 1455, the Seljuks land on Sicily, conquering it completely in 1456.
1466: The infamous Sacco di Roma happens. In the following years, the church loses a lot of power to the various state governments (whether monarchical, republican or something in between). Castille-Portugal sends troops to Italy to fight for the pope.
1472: After lots of fighting, the Seljuks keep Latium, calling themselves from now on "rulers of both Romes". Despite the fact that the sultan is disappointed how insignificant Rome has become. The eastern parts of the Papal states become the Duchy/Protectorate of the Marches, theoretically still under the pope, de facto under the duke of Alba (Castile). Although none say it loud, the pope and the other church leaders are quite content in Avignon and don't care that much about Rome any more.
1496: Cyprus conquered by Rum-Seljuks.
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