Mary of Spain was born in Brussels on 15 September 1505 to Philip I of Castile and Joanna I of Spain and was a sibling to the holy roman emperor Charles V. Her marriage was arranged after the death of Vladislaus II of Hungary and Bohemia and upon his son Louis's succession, also their siblings Duke Ferdinand of Austria and Anne of Hungary married. She was a traditional Habsburg and pushed his husband to attack the Turks all the time. She was clearly upset when her husband died and she and their son Casimir I had to escape the wrath of the Turks. In 1523 she followed her husband into a war against the Lutherans. After Casimir in 1530, they had another child - Agnes - in 1532. When she became the queen mother and her son was crowned in Prague, she was very fond of her son and his relatives (Sigismund I and II and Charles V's cleansing of Hungary from the Turks and, in fact, wanted Popes Alexander VII and Gregory XIII to make him a saint while still alive, she died in 1569 and was buried in Prague, where she spend most of her son's reign.