The First Ottoman-Venetian War (1463 - 1466) was a military and naval engagement fought between the Republic of Venice and her allies, and the Ottoman Empire, from 1463 to 1466. The war was fought years after the fall of the city of Constantinople and the ancient Byzantine Empire by the Ottomans, resulting in the loss of a few Venetian holdings in Greece and Albania.
The peace, signed at the port city of Smyrna, was a key factor in the initial victories in the later Ottoman-Italian Wars, as the agreements set by the Ottomans ensured non-aggression and the neutrality of Venice in future conflicts. The war also saw the rapid expansion of the Ottoman navy, and with the cession of numerous Venetian high-end vessels, brought a warning to the Venetians to beware of their holdings outside of Italy. This caution caused the Republic to seek alternative routes to the sea other than by the Adriatic Sea, worried the Ottomans may cut off their route at any moment.