The Eastern Establishment is a term often used to refer to the powerful interests that generally controlled the National Party during the mid-20th century, in particular following the aligning 1928 Presidential election. The Eastern Establishment was typified by its alliance with the financial industry, its relationships with wealthy middle and upper class people in New England, New York and the Atlantic states, and its struggles with the other three wings of the party - the conservative, isolationist and working-class Midwest, the libertarian West and its relationships with the Cosmopolitans in the South.

Prominent members of the Eastern Establishment included United States President Prescott Bush, Vice President Thomas Dewey, Senators such as Edmund Dawes, John Roy and William Durant, Congressmen such as Peter Criss, Albert E. Quade, George F. Duckett, and C.E.R. Howard. Generally, the Eastern Establishment supported international engagement, free trade, moderate social policies, low taxes, and generally adopted a pro-business attitude.

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