The Cherokee War of Independence (1841-42) was a successful revolt against the Confederacy of American United States by the Cherokee Nation.

In 1829-1830, 7th President Andrew Jackson signed the Indian Removal Acts, starting the infamous Trail of Tears and relocated the Cherokee Nation and other tribes to the Oklahoma Territory.

After Jackson's assassination in 1835 and American Civil War, the recuperating tribes united and struck the war weakened C.A.U.S. a crucial blow, resulting in the Treaty of Delaware, in which the Cherokee Nation retained their Oklahoma lands, as well as regained their ancestral homelands in the Southern Confederacy.

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