Benvolio II was the oldest of his fathers' three surviving children. An older brother and sister, as well as two younger sisters, both died in infancy. His siblings who lived do adulthood were Girona and Angela.
Benvolio was age two when the Neapolitan Civil War began. His father was a powerful warlord during this war, and following the conclusion in 1611, Benvolio was the crown prince of the kingdom. He received the best education that could be taught in Naples at that time, and became deeply religious. In 1631, he married Maria Caligari, and they had two surviving children, Angelo and Joan.