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- 21 November: Barbados - A nineteen-year-old man from Virginia by the name George Washington dies from smallpox on the island of Barbados in the Caribbean Sea while accompanying his older half-brother Charles to the island to see if it would help with his tuberculosis. (Point of Divergence)
- 24 August: New France - The Canadien colonial military commander, Jacques Legardeur de Saint-Pierre, dies from a gunshot wound to the stomach that he received from a drunk commoner in Montreal.
- 29 October: New France - Paul Marquis de la Malgue dies, the commander of French garrisons in the Ohio Country at the time, dies. His replacement is Claude-Pierre Pécaudy de Contrecœur, an officer from the colonial regular troops.
- 21 October: Virginia - Lieutenant Governor Robert Dinwiddie commissions Colonel Joshua Fry to dissuade the French from occupying the Ohio Country.
- 12 December: Ohio Country -